Ironing out neurodegeneration: Iron chelation for neuroprotection
نویسندگان
چکیده
منابع مشابه
Ironing out the problem: new mechanisms of iron homeostasis.
For most organisms, iron is an essential nutrient that is both difficult to acquire from the environment and toxic at high concentration. Therefore, to avoid deprivation or over-abundance of iron, bacteria and eukaryotes have developed a tight regulatory system to keep the metal within a narrow concentration range. Recent work in the bacteria Escherichia coli and in Pseudomonas aeruginosa has d...
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New insights into the roles of proteins that regulate cellular iron in cancer growth, angiogenesis, and metastasis have recently emerged. Discoveries of the roles of ferroportin, hepcidin, lipocalin 2, and members of the six transmembrane epithelial antigen of the prostate (STEAP) and iron regulatory protein (IRP) families in cancer have provided specificity and molecular definition to the role...
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Maintaining physiologic iron concentrations in tissues is critical for metabolism and host defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes, and iron mobilization from storage in macrophages and hepatocytes constitute the major iron flows into plasma for distribution to tissues, predominantly for erythropoiesis. All iron transfer to plasma occurs through t...
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Women who are not anemic but who suffer from fatigue may benefit from iron supplementation. In this issue of Blood, Krayenbühl et al provide strong evidence that women complaining of fatigue who were not anemic but who had reduced or absent iron stores were symptomatically improved after receiving parenteral iron. Given the numbers of women who are iron deficient, the findings could find broad ...
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The increasing prevalence of obesity and the metabolic syndrome worldwide is well recognized, the tight association of non-alcoholic fatty liver disease (NAFLD) with these conditions increasingly so. NAFLD can progress to the more severe form of the disorder non-alcoholic steatohepatitis (NASH), which is characterized by worsening liver pathology. The prevalence of iron disorders, in particular...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2011
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2011.05.009